The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury in Total Knee Arthroplasty

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01638624

Enrollment

Registered

2012-07-12

Start date

2012-06-30

Completion date

2012-11-30

Last updated

2016-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total Knee Arthroplasty, Tourniquet-Induced Ischemia-Reperfusion Injury

Keywords

Propofol, antioxidant capacity, total knee arthroplasty, Propofol,antioxidant

Brief summary

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers. Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Interventions

DRUGPropofol

Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol.

DRUGPlacebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ASA I-II physical status * Unilateral total knee arthroplasty * Age 18 years to 80 years

Exclusion criteria

* Severe central nervous system disorders * Severe cardiopulmonary,renal,metabolic, or hepatic disease, * Blood volume deficits, * Coagulopathy, * Allergy to local anesthetics, * Peripheral neuropathies, * Body mass index \> 35, * History of antioxidant drug use

Design outcomes

Primary

Measure	Time frame	Description
The perioperative alternation of the venous blood total antioxidant capacity levels of the arms	T1,T2,T3	T1 : Before the spinal anesthesia performed T2 : At 30th min of tourniquet inflation T3 : At 2nd hours of tourniquet deflation

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026