Resistance Training in Diabetic Elder Patients

Effects of Resistance Training on Muscle Dysfunction in Elderly Patients With Type 2 Diabetes Mellitus

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01638351

Enrollment

Registered

2012-07-11

Start date

2011-12-31

Completion date

2012-10-31

Last updated

2012-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Type 2

Keywords

Diabetes mellitus, Resistance exercise, Elderly, Skeletal muscle dysfunction, Metabolomics

Brief summary

The purpose of this study is to investigate the effect of a 12-week progressive resistance training program on the skeletal muscle function, glycemic control, functional capacity, and quality of life in the elderly with type 2 diabetes mellitus.

Interventions

BEHAVIORALResistance exercise

Progressive resistance exercise training, 3 times a week for 12 weeks.

BEHAVIORALUsual care

Participants in this arm will receive a brochure specific for type 2 diabetes mellitus about the general principles of exercise, nutrition, and diet. They are asked to maintain their activity level.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

65 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* 65 years old or older * no clinical diagnosis of cardiovascular disease * patients with or without type 2 diabetes mellitus

Exclusion criteria

* glycated hemoglobin \> 10% * pulmonary disease * cancer * cognitive dysfunction * any neurological or musculoskeletal disease that will affect exercise performance

Design outcomes

Primary

Measure	Time frame	Description
Maximal muscle strength	Twelve weeks	This outcome measure includes upper and lower body maximal muscle strength.

Secondary

Measure	Time frame	Description
Quality of life	Twelve weeks	This outcome measure will be assessed by the diabetes-specific questionnaire.
Waist circumference	Twelve weeks	—
Body mass index	Twelve weeks	This outcome measure includes the measurements of body height and body weight.
Physical body function	Twelve weeks	This outcome will be assessed by one minute sit-to-stand test and timed Up and Go test.
Blood biochemical parameters	Twevle weeks	This outcome measure includes the analysis of fasting glucose, glycated hemoglobin, lipid profile, C-reactive protein, and related metabolites.
Muscle oxygenation	Twelve weeks	Muscle oxygenation will be assessed during exercise
Functional capacity	Twelve weeks	Peak oxygen consumption will be determined by graded exercise test to assess functional capacity.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026