Identification of Correlates of Protection Against Shigella and Enterotoxigenic Escherichia Coli Infections

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01638039

Enrollment

330

Registered

2012-07-11

Start date

2012-07-31

Completion date

2016-07-31

Last updated

2012-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dysentery

Brief summary

The aim of this study is to accelerate the development of vaccine candidates against diarrheal diseases caused by Shigella and Enterotoxigenic Escherichia coli (ETEC). We plan to identify cases of laboratory-proven shigellosis and ETEC-associated diarrhea, to study humoral and cellular immune parameters following natural infections with Shigella and ETEC, and to compare the level of pre-existing local, humoral and cellular immune parameters in cases of shigellosis and ETEC-associated diarrhea and in matched controls.

Interventions

OTHERLaboratory Tests

Stool, blood, urine and saliva samples

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Lab-confirmed Shigella or ETEC * Individuals or patients without diarrheal disease

Exclusion criteria

* n/a

Design outcomes

Primary

Measure	Time frame	Description
Identification of cases of shigellosis and ETEC-associated diarrhea	Four years	Stool of patients examined in laboratory and identified as infected with the pathogens

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026