Anuria, End Stage Renal Disease, Peritonitis
Conditions
Keywords
peritoneal dialysis, dose, residual kidney function, technique survival, patient survival, peritonitis
Brief summary
The purpose of this study was to explore the impacts of different continuous ambulatory peritoneal dialysis (CAPD) dosage (three 2-Liter exchanges CAPD vs. four 2-Liter exchanges CAPD) on residual kidney function, technique survival, patient survival, and peritonitis in incident Chinese peritoneal dialysis patients.
Detailed description
1. The primary end point for this study was changes in residual kidney function including GFR, daily urine volume (Uvol), and anuria-free survival. GFR and Uvol were evaluated within 1 week before CAPD initiation (the baseline), and then at month 1, 6, 12, 18 and 24. At the same time, body weight, blood pressure, daily net ultrafiltration, dialysis adequacy, peritoneal solute transport rate, and biochemical parameters etc. were assessed. Once an episode of peritonitis or other serious reversible intercurrent illness occurred, all the assessments were delayed one month after being cured. Anuria was termed by daily Uvol permanently less than 100 ml. 2. The secondary end points included technique survival, patient survival and peritonitis. Technique failure was defined as switching to maintenance hemodialysis.
Interventions
OTHERThree 2-liter exchanges daily CAPD
CAPD regimen of three 2-liter daily exchanges
OTHERFour 2-liter exchanges daily CAPD
CAPD regimen of four 2-liter daily exchagnes
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* incident CAPD patients aged 18 to 80 years * GFR ≥ 2 ml/min and Uvol ≥ 500 ml/day
Exclusion criteria
* have a history of maintenance hemodialysis or renal transplantation * anticipated life expectancy less than 6 months * with active malignancy, acute infection, significant heart failure or in other severe conditions * unable to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Residual kidney function including glomerular filtration rate (GFR), daily urine voume (Uvol), and anuria-free survival. | Up to 24 months after CAPD initiation | GFR was calculated by the mean of renal clearance of urea and creatinine from a 24-h urine collection. Anuria was termed as consistently Uvol \< 100 ml/day for more than a month. |
Secondary
| Measure | Time frame |
|---|---|
| Number of participants having technique failure refering to switching to maintenance hemodialyisis | Up to 24 months after CAPD initiation. |
| Number of participants died | Up to 24 months after CAPD initiation |
| Episodes of peritonitis | Up to 24 months after CAPD initiation |
Countries
China
Outcome results
None listed