Urolithiasis
Conditions
Keywords
urine, stool, kidney stones
Brief summary
The purpose of this study is to add to the investigators' quest to understanding stone disease, by evaluating the metabolites excretion in urine and its relation to microflora present in the stool.
Detailed description
Kidney stones affect up to 10% of the Canadian population and can lead to pain, hospitalization, lost of time at work, and surgery. Approximately 80% of stones consist of calcium and oxalate, of which both components come from diet and normal bodily processes. Individuals who have high levels of oxalate in their urine have a greater tendency to generate stones. One recommendation is to reduce their intake of oxalate-containing foods, but many healthy foods contain oxalate, and an oxalate-free diet is unpalatable and difficult to achieve. Some patients, despite reducing their oxalate intake, still have high amounts in the urine. Intestinal metabolism is largely affected by the state and composition of the intestinal bacterial flora, with several metabolic diseases being linked to a disrupted normal intestinal flora. The investigators believe that calcium oxalate stone disease as well as high urinary levels of oxalate (hyperoxaluria) are triggered by inefficient oxalate metabolism in the intestine, which is linked to a disrupted intestinal bacterial flora that lacks certain key components such as O. formigenes. The long-term purpose of this study is therefore, to determine the effect of replenishing the intestinal flora of patients with that of normal controls, thereby re-introducing a balanced environment that will lead to the re-establishment of normal metabolic functions and a decrease in urinary oxalate levels and hopefully lower incidence of stone disease.
Interventions
None listed
Sponsors
University of British Columbia
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
Controls * Age \> 19. * No history of kidney stone disease Study Patient (Stone Patient) * Age \> 19 * Radiological evidence indicating presence of a current renal or ureteric stone
Exclusion criteria
* Pregnancy * Positive Urine Culture * Active cancer * Recurrent urinary infections * Gross hematuria * Inability to provide informed consent * In the Investigator's opinion, the patient would not be good for the study. Controls Only: * Family history of kidney stones * History of kidney stones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bacterial flora in the intestine of patients with kidney stones compared to non-stone forming individuals | one day of urine and stool collection | The objective of this study is to compare the bacterial flora in the intestine of patients with kidney stones compared to non-stone forming individuals. If there are differences between stone forming and non-stone forming individuals in the content of their bacterial flora, these will also be correlated with levels of metabolites found in the urine that are known risk factors of stone disease. Difference in bacterial intestinal flora already exists for patients who are obese compared to non-obese individuals. |
Countries
Canada
Contacts
Primary ContactOlga Arsovska, BSc
Outcome results
None listed