Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty

Plasma Concentrations of Bupivacaine After Spinal Anesthesia With Single Shot Femoral Nerve Block and Peri-articular Injection in Total Knee Arthroplasty

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01636869

Enrollment

Registered

2012-07-10

Start date

2012-07-31

Completion date

2014-07-31

Last updated

2014-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periarticular Block, Serum Bupivacaine Level, Total Knee Arthroplasty

Keywords

bupivacaine level, periarticular block, total knee arthroplasty

Brief summary

Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.

Interventions

DRUGBupivacaine

20 ml of 0.5% bupivacaine for single-shot femoral nerve block will be done at the beginning then another 20 ml of 0.5% bupivacaine for periarticular block will be performed at the end of operation. Blood sample will be drawn at 60 min after femoral nerve block and before periarticular block, 15, 30, 45, 60 min after periarticular block.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 70 Years

Healthy volunteers

Inclusion criteria

* age of 30-70 yr * ASA I-II * patient undergo total knee arthroplasty under spinal block and single shot femoral nerve block and periarticular block

Exclusion criteria

* patient's refusal * allergic to bupivacaine * body weight less than 50 kg * liver disease * heart disease * coagulopathy * Hct\<35% * infection at both groin

Design outcomes

Primary

Measure	Time frame
plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block	2 hours

Secondary

Measure	Time frame
bupivacaine toxicity	24 hr

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026