Effectiveness of Internet-based Depression Treatment

Conditions

Mild to Moderate Depressive Symptoms

Brief summary

Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of mild to moderate depressive symptoms. Participants will be randomised to either twelve weeks of online-self help or a waiting-list control. Symptoms of depression and other aspects will be assessed over a one year period. Thereafter the controls will also receive online-self help. The investigators hypothesise that online self-help is superior to the control condition in alleviating depressive symptoms and preventing full blown depression.

Detailed description

This study is supported by the German Ministry of Health (BMG) and is a collaborative project of Universität Bern (PD Dr. Thomas Berger), Charité Berlin (PD Dr. Matthias Rose), Universität Bielefeld (Prof. Dr. Wolfgang Greiner), Universität Hamburg (Prof. Dr. Steffen Moritz, Prof. Dr. Bernd Löwe), GAIA AG Hamburg (Dr. Björn Meyer), Universität Tübingen (Prof. Dr. Martin Hautzinger) and Universität Trier (Prof. Dr. Wolfgang Lutz).

Sandra Nolte, Lucy Busija, Thomas Berger, Björn Meyer, Steffen Moritz et al. (9 authors)

BMJ Open2021-01-019 citations

10.1136/bmjopen-2020-041389

Identifying change-dropout patterns during an Internet-based intervention for depression by applying the Muthen-Roy model.

Alice Arndt, Wolfgang Lutz, Julian Rubel, Thomas Berger, Björn Meyer et al. (13 authors)

PubMed2020-01-0114 citations

10.1080/16506073.2018.1556331

Time to remission from mild to moderate depressive symptoms: One year results from the EVIDENT-study, an RCT of an internet intervention for depression.

Klein JP, Späth C, Schröder J, Meyer B, Greiner W, Hautzinger M, Lutz W, Rose M, Vettorazzi E, Andersson G, Hohagen F, Moritz S, Berger T.

2017-07-2118 citations

10.1016/j.brat.2017.07.013

Does recruitment source moderate treatment effectiveness? A subgroup analysis from the EVIDENT study, a randomised controlled trial of an internet intervention for depressive symptoms

Jan Philipp Klein, Carla Gamon, Christina Späth, Thomas Berger, Björn Meyer et al. (11 authors)

BMJ Open2017-07-0125 citations

10.1136/bmjopen-2016-015391

The EVIDENT-trial: protocol and rationale of a multicenter randomized controlled trial testing the effectiveness of an online-based psychological intervention.

Klein JP, Berger T, Schröder J, Späth C, Meyer B, Caspar F, Lutz W, Greiner W, Hautzinger M, Rose M, Gräfe V, Hohagen F, Andersson G, Vettorazzi E, Moritz S.

2013-09-2840 citations

10.1186/1471-244x-13-239

Interventions

BEHAVIORALDeprexis

Online self-help with and without e-mail-support

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

No

Inclusion criteria

* PHQ\>4 and \<15

Exclusion criteria

* acute suicidality * psychotic d/o, bipolar d/o or other severe psychiatric d/o

Design outcomes

Primary

Measure	Time frame
Personal Health Questionnaire (PHQ-9)	12 wks

Secondary

Measure	Time frame
Hamilton Rating Scale for Depression (HRSD)	12 wks, 6 mths, 12 mths
Quick Inventory of Depressive Symptoms (QIDS)	12 wks, 6 mths, 12 mths
Personal Health Questionnaire (PHQ-9)	6 mths, 12 mths

Countries

Germany

Outcome results

None listed