Hypertension, Metabolic Syndrome, Obesity, Type 2 Diabetes
Conditions
Keywords
Type 2 diabetes, hypertension, obesity, metabolic syndrome
Brief summary
The present study investigates the effects of recreational soccer in type 2 diabetic men in regard to muscular, cardiovascular adaptations and glycaemic control. 12 men participate in 6 month structured recreational soccer training and 10 men act as control with no change in lifestyle. Testing consisting of fasting blood samples, muscle biopsies, Dexa-scans, echocardiography, maximal oxygen consumption, Yo-Yo interval test, bloodpressure, Resting heart rate, and endothelial function (Itamar, Endopat)will be performed at baseline, after 12 and 24 weeks, respectively. The study examines the hypothesis that the high-intensity aerobic work profile combined with a high anaerobic turnover from the nature of soccer (accelerations, decelerations, turns, sudden stops) will improve glycaemic control, muscle and cardiac function and taken together will improve the overall health profile in type 2 diabetic men
Interventions
OTHERsoccer exercise or continued daily lifestyle
Recreational soccer or continued unchanged lifestyle
Sponsors
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
35 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Type 2 diabetes diagnosed * 35-60 years old men
Exclusion criteria
* Smoker * Ischaemic heart Disease * Congestive heart failure * Joint or limp pains to an extent where recreational soccer can not be performed. * Apoplexia. * Anticoagulant therapy (aspirin accepted)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac adaptations | Analysis of data at baseline, 12 and 24 weeks | All participants are examined with 2d- echocardiography, speckletracking, strain and colordoppler |
| muscular adaptations | Data analysis after baseline, 12 and 24 weeks | muscle biopsies are obtaned from the vastus lateralis muscle at baseline, after 12 and 24 weeks, respectively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vascular function | Data analysis after baseline, 12 and 24 weeks | All subjects are examined with peripheral arterial tonometri (endopat). Plasma samples and muscle biopsies are analyzed for relevant markers of vascular function |
| glycaemic control | Data analysis after baseline, 12 and 24 weeks | HbA1c, insulin and C-peptide are meassured at baseline, after 12 and 24 weeks, respectively |
Countries
Denmark
Outcome results
None listed