Bicarbonates Versus Saline for Contrast Induced Acute Kidney Injury Prevention in Intensive Care Unit

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01636089

Acronym

HYDRAREA

Enrollment

300

Registered

2012-07-10

Start date

2012-02-01

Completion date

2015-01-01

Last updated

2026-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast Induced Acute Kidney Injury

Keywords

intensive care unit

Brief summary

The aim of this study is to compare bicarbonates versus saline for prevention of contrast induced acute kidney injury in critically ill patients.

Interventions

DRUGbicarbonates

sodium bicarbonates 1,4%

DRUGsaline

sodium chloride 0,9%

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient \> 18 years old * in intensive care unit since 24h and for up to 48 hours * with contrast medium injection

Exclusion criteria

* patient under renal replacement therapy * rise in creatinine \> 26µmol/L within 48hours * anuria within 12 hours * cardiogenic pulmonary oedema * pH \> 7.50 or kaliemia \< 3mmol/L * pregnancy

Design outcomes

Primary

Measure	Time frame
contrast induced acute kidney injury	72 hours

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026