Small Cell Carcinoma of Lung
Conditions
Keywords
Irinotecan, UGT1A1 Gene Polymorphisms, Small Cell Carcinoma of Lung
Brief summary
The purpose of this study is to find out the correlation between uridine diphosphate glucuronosyl transferase 1A1(UGT1A1) gene polymorphisms and the side effect and efficacy of irinotecan in patients with small cell lung cancer.
Detailed description
In multiple studies of metastatic colorectal cancer,uridine diphosphate glucuronosyl transferase 1A1(UGT1A1) gene polymorphisms and its correlation with irinotecan-associated side effects have been confirmed.Data from several studies indicated an improved clinical outcome of patients who had received an irinotecan-based regimen.In order to find out the correlation between UGT1A1 gene polymorphisms and the side effect and efficacy of irinotecan in patients with small cell lung cancer,we designed this study.
Interventions
DRUGIrinotecan
irinotecan 180mg/m2 i.v. over 30 min d1,q2w
Sponsors
Zhejiang Cancer Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of refractory or relapsed small cell lung cancer * Physical examination and routine laboratory tests show no contraindications to chemotherapy
Exclusion criteria
* Pregnant and nursing women * Brain metastasis with symptoms
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Side effect of chemotherapy | within the first 30 days (plus or minus 3 days) after chemotherapy | myelosuppression,diarrhea |
Secondary
| Measure | Time frame |
|---|---|
| response rate of chemotherapy | tumor assessments after two cycles of chemotherapy,an expected average of 6 weeks |
Countries
China
Contacts
Primary ContactFan Yun
Outcome results
None listed