Trends of Morbidity and Mortality Among Thai HIV-infected and HIV-uninfected Patients: a Five-year Prospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01634477

Acronym

TNT-HIV

Enrollment

816

Registered

2012-07-06

Start date

2010-01-31

Completion date

2021-07-31

Last updated

2024-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, HIV Infection

Keywords

morbidity, mortality, HIV-infected patients, prospective cohort study, highly active antiretroviral therapy (HAART), opportunistic infections, Non HIV-related illness, cardiovascular disease (CVD), HIV negative patients, Thai HIV-infected patients

Brief summary

1. To describe the morbidity and clinical characteristics among HIV-infected patients and HIV-uninfected patients. 2. To identify the risk factors for the complication or morbidity among HIV-infected patients and HIV-uninfected patients. 3. To describe the mortality among HIV-infected patients and HIV-uninfected patients. 4. To identify the risk factors for the cause of death among HIV-infected and HIV-uninfected patients.

Detailed description

The information obtained from this study would be very important in planning future holistic care of HIV-infected patients in our institutes as well as in national policy. Results from the study could be used to develop proper long-term management guidelines for people living with HIV (PLHIV) in Thailand targeted at preventable conditions such as metabolic diseases and certain cancers.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

HIV-infected patients group * HIV positive * 30 years of age or older, both male and female * Thai nationality * Written research informed consent HIV-uninfected patients group * HIV un-infected * 30 years of age or older, both male and female * Thai nationality * Written research informed consent

Exclusion criteria

HIV-infected patients group * Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment * Fasting blood sugar \> 126 mg/dl or on the treatment * Proteinuria * Creatinine \> 1.5 mg/dl * Recent hospitalization * Patient who are having mental disease HIV-uninfected patients group * Systolic BP ≥ 130 or Diastolic BP ≥ 85mm Hg or on the treatment * Fasting blood sugar \> 126 mg/dl or on the treatment * Proteinuria * Creatinine \> 1.5 mg/dl * Recent hospitalization * Patient who are having mental disease

Design outcomes

Primary

Measure	Time frame	Description
morbidity	60 months	development of other diseases
HIV related illness	60 months	development of opportunistic infection such as Non-Hodkin's lymphoma, Kaposi's sarcoma
Non HIV-related illness	60 months	development of Dyslipidemia, Hypertension, DM, CVD , Cancer, osteopenia, osteoporosis, Renal disease, liver disease
mortality	60 months	death
CVD	60 months	development of CVD

Countries

Thailand

Outcome results