Mental Disorders, Substance-Related Disorders
Conditions
Keywords
cognitive remediation therapy, substance abuse treatment
Brief summary
The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.
Detailed description
Forty individuals seeking treatment for an alcohol or cocaine use disorder at the Substance Abuse Treatment Unit (SATU) will be randomized to receive cognitive remediation therapy with or without additional compensation based on performance. Participants will use the computerized cognitive remediation program (PSSCogRehab 2012) three times per week for four weeks. The primary outcome measure will be an improved performance on the computerized tasks, with secondary outcomes of changes in cognitive functioning (e.g., attention, concentration, memory) as measured by neuropsychological tests between baseline and post-treatment.
Interventions
BEHAVIORALCognitive Remediation Therapy - Standard
Computerized cognitive remediation therapy provided three times per week for four weeks
BEHAVIORALCognitive Remediation Therapy plus Contingency Management
Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.
Sponsors
National Institute on Drug Abuse (NIDA)
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* 18 to 60 years old * Primary Alcohol and/or Cocaine Abuse/Dependence Diagnosis * Abstinence from all drugs/alcohol for 30 days * Mild cognitive impairment * Sufficiently stable and plan to commit to 4 weeks of outpatient treatment * Fluent in English and 6th grade reading ability
Exclusion criteria
* Severe cognitive impairment indicative of dementia * Untreated bipolar or psychotic disorder * Have current legal case pending such that incarceration during 4-week study is likely
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in performance scores on computerized cognitive remediation tasks | 4 weeks | Performance scores on various computerized cognitive remediation tasks will be measured repeatedly during the 4 week study. These scores include time to completion, number of errors, number of words correctly recalled, and percentage of task completed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improved cognitive function on neuropsychological tests | 4 weeks | Change in cognitive function between baseline and post-treatment will be measured by performance on neuropsychological tests, such as Trail Making Test A & B, Wisconsin Card Sort Test, Digit Symbol Test from WAIS-IV, and the Continuous Performance Test-II (CPT-II). |
Countries
United States
Outcome results
None listed