Child, Critical Illness, Heart Defects, Congenital, Mental Processes
Conditions
Keywords
neurocognitive testing, critical illness, executive function, intelligence
Brief summary
The key objective of the Leuven growing-into-deficit (GID) follow-up-study is to test the hypothesis that children with a congenital heart disease (CHD) show more neurocognitive impairment at the second follow-up at 7 years old than at the first follow-up at the age of 4, compared to healthy controls.
Interventions
None listed
Sponsors
KU Leuven
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
84 Months to 89 Months
Healthy volunteers
Yes
Inclusion criteria
* Seven-year-old children with CHD and healthy control children who were four years old when they participated in Paediatric ICU follow-up study (i.e. first follow-up time point) (Neurocognitive development of children four years after critical illness and treatment with tight glucose control, Clinical Trials # NCT00214916). The children of the CHD-group underwent cardiac surgery as infants (=\<1year).
Exclusion criteria
* Genetic syndromes (Down, 22q11del), known to result in neurocognitive impairment * IQ \< 70 * Lack of baseline neurocognitive measurements during first follow-up * Date of birth before February 2005
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| reaction time (RT) and error rates of inhibitory control (Response Organization Objects, ROO) (Amsterdam Neuropsychological Tasks, ANT) | one testpoint at age of 7 years |
Secondary
| Measure | Time frame |
|---|---|
| Mean RT + standard deviation (SD) of RT on computerized alertness task (Baseline Speed, ANT) | one testpoint at age of 7 years |
| Number of taps on computerized tapping tasks (ANT) | one testpoint at age of 7 years |
| IQ measures (Revised Wechsler Preschool and Primary Scale of Intelligence, WPPSI-R) | one testpoint at age of 7 years |
| Visual-Motor Integration total standard score (VMI) | one testpoint at age of 7 years |
| reaction time (RT) and error rates of cognitive flexibility (ROO, ANT) and working memory (Memory Search - Objects 2 Keys, ANT) | one testpoint at age of 7 years |
| Pediatric Quality of Life Inventory - Generic Score Scales (PedsQL) to quantify quality of life | one testpoint at age of 7 years |
| Behavior Rating Inventory of Executive Function (BRIEF) to measure executive functions (parent and teacher version) | one testpoint at age of 7 years |
| Teacher Report Form (TRF) T-scores for internalizing and externalizing problems at school | one testpoint at age of 7 years |
| Incidence of medical problems (e.g. head trauma), interventions and operations since first follow-up | one testpoint at age of 7 years |
| Child Behavior CheckList T-scores for internalizing and externalizing problems | one testpoint at age of 7 years |
Countries
Belgium
Outcome results
None listed