Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome

Assessment of Small Intestinal Bowel Epithelial Gaps in Patients With Irritable Bowel Syndrome by Confocal Laser Endomicroscopy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01632488

Enrollment

Registered

2012-07-03

Start date

2012-06-30

Completion date

2012-12-31

Last updated

2012-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Disease, Irritable Bowel Syndrome

Keywords

Irritable Bowel Syndrome, Inflammatory Bowel Disease, Confocal Laser Endomicroscopy

Brief summary

The study aims to: 1. Determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (IBS) is different from that in inflammatory bowel disease (IBD) patients and normal controls by confocal laser endomicroscopy (CLE). 2. Evaluate the relationship between the density of epithelial gaps and IBS subtypes, and visceral hypersensitivity.

Detailed description

Epithelial cells lining the gastrointestinal tract serve as a barrier between the gut lumen and the body. Previous study has shown that epithelium is punctuated by discontinuities named gaps. Confocal laser endomicroscopy could be used as a useful tool for detecting epithelial gaps in vivo, and epithelial gap density in terminal ileum of IBD patients was elevated compared with normal control using CLE. So this study aims to determine whether the density of epithelial gaps in terminal ileum of patients with IBS is different from that in IBD patients and normal controls by CLE, and to evaluate the relationship between the density of epithelial gaps and IBS subtypes, and visceral hypersensitivity.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Bowel habits alterations meeting IBS Rome III criteria and indications for colonoscopy investigation * Patients with history of inflammatory bowel disease * Asymptomatic individuals for health surveillance or patients for follow up after polypectomy * Patients complained of hemafecia but colonoscopy revealed only haemorrhoid

Exclusion criteria

* Patients with known cancers or abdominal surgery * Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass * Patients who are unwilling to sign or give the informed consent form * Patients who are allergic to fluorescein sodium * Patients with impaired cardiac, liver or renal function * Patients with coagulopathy * Patients with pregnancy or breastfeeding

Countries

China

Contacts

Primary ContactYanqing Li, MD, PhD

liyanqing@sdu.edu.cn86-531-8216923

Outcome results