Smoking
Conditions
Keywords
Smoker, Non-Smoker, Healthy, Drug free, MRI
Brief summary
The purpose of this study is to see how the brain differs between smoking regularly and after not smoking for 24 hours. The investigators will be using an MRI machine to get the information from adult smokers and non-smokers while they lie in the scanner with their eyes closed. Smokers will be scanned when they have not smoked for 24 hrs and shortly after smoking. It is our hypothesis that brain activity will be altered after not smoking for 24 hours.
Detailed description
The broad objective of this proposal is to identify functional neuroanatomical correlates of changes in brain functional connectivity during smoking abstinence. The investigators will measure changes in regional blood oxygenation levels using fMRI while adult smokers and non-smokers lie in the scanner with their eyes closed. Smokers will be scanned when they are abstinent from smoking for 24 hrs and shortly after smoking. Our primary hypothesis is that smoking abstinence will alter resting state brain activity (or resting state functional connectivity; RSFC) across widely distributed neural networks and that high-resolution fMRI will help in resolving the exact nature of such changes. Data will be analyzed using methods developed in our laboratory and applied to other resting state datasets. All of the procedures used in the study are well validated and introduce only minor risk to participants (e.g. blood draw; MRI).
Interventions
BEHAVIORALAbstain from smoking for 24 hours
Compare smoking satiation to 24 hour smoking abstinence
Sponsors
National Institute on Drug Abuse (NIDA)
Duke University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Right handed * Drug free * No known health problems * Currently not taking any medication * Uninterested in quitting smoking long term
Exclusion criteria
* Left handed/ambidextrous * Currently taking medication * Interested in quitting long term
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood-oxygen-level-dependent (BOLD) signal | following smoking cigarette 30 minutes prior to scan | Smokers will be scanned after smoking to satiety. In order to be considered satiated, smokers will have to be regular smokers (smoking daily for at least 2 years). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood-oxygen-level-dependent (BOLD) signal | 24 hours abstinence | Smokers will be asked to stop smoking 24 hours prior to the scan without the aid of nicotine replacement therapies. They will resume smoking as usual 24 hours after the scan. |
Countries
United States
Outcome results
None listed