Sepsis, Septic Shock
Conditions
Keywords
ADMA, DDAH II, SAPS, SOFA, Sepsis, Procalcitonin, ICU, mortality, length of stay
Brief summary
Examination of ADMA (Asymmetric-Dimethylarginine)-serum level and DDAH II (Dimethylarginine Dimethylaminohydrolase)- Polymorphism in patients with severe Sepsis and septic shock as prognostic value. This study looks into ADMA as a good prognostic factor for sepsis. Further more the dependency of the ADMA level to the DDAH II polymorphisms is reviewed this study.
Detailed description
Secondary targets are the mortality (28 days ICU), the length of hospitalisation in ICU and peripheral station, the severity of the illness (SAPS II score), the SOFA-score values in the progress and the procalcitonin values in the progress
Interventions
None listed
Sponsors
Universitätsklinikum Hamburg-Eppendorf
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>18 y/o * sepsis * septical shock
Exclusion criteria
* primary cardiogenic shock * pregnancy * breastfeeding * non compliance * moribund status
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ADMA serum levels | 7 days | measuring of ADMA serum levels on day 1, 3, 7 |
Secondary
| Measure | Time frame |
|---|---|
| 28 day mortality | 28 day |
| hospitalisation (ICU and peripheral) | 28 days |
| severity of illness | 28 days |
| DDAH Ii polymorphism | 28 days |
Countries
Germany
Outcome results
None listed