Infection After Primary Total Knee Arthroplasty
Conditions
Brief summary
Prospective randomized study in cemented primary total knee arthroplasty. In one group the cement used was standard cement, without any antibiotics and in the other group the cement used was loaded with 0.5 g of erythromycin and 3 million units of colistin in 40 g of cement. In all cases intravenous antibiotics prophylaxis against infection was used. In both groups the cement was mechanically mixed in a vacuum. One deep drain tube was placed for 24 hours in all cases. The main variable was the presence of infection according to the Center of Disease Control criteria with a minimum of 12 months follow-up.
Interventions
PROCEDURECement without antibiotic.
PROCEDURECement with erytromycin and colistin.
Sponsors
Parc de Salut Mar
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Primary total knee replacement. Both genders. No age limits.
Exclusion criteria
* Allergy to erythromycin or colistin. Previous infection in the knee.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Infection | The minimum follow-up is 12 months. | Presence or absence of infection, according to the Center for Disease Control's criteria. The infection cases are classified as superficial of deep infection. |
Countries
Spain
Outcome results
None listed