Euthyroid Sick Syndrome
Conditions
Keywords
Euthyroid Sick Syndromes, Thyroxine, Intensive care
Brief summary
The purpose of this study is to determine whether levothyroxine is effective and safe in the treatment of children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit.
Detailed description
Children with euthyroid sick syndrome, hospitalized in a pediatric intensive care unit, will be randomised to receive either Levothyroxine or placebo, to determine if it diminishes mortality.
Interventions
DRUGLevothyroxine
3 mcg/kg/day
OTHERCalcium magnesia
Placebo.
Sponsors
Sinaloa Pediatric Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Months to 17 Years
Healthy volunteers
No
Inclusion criteria
* All children aged 1 month to 17 years. * Admitted to pediatric intensive care unit. * TSH and thyroid hormones below age specific levels.
Exclusion criteria
* Known thyroid condition. * Brain death. * Gut conditions that contraindicate oral route. * Readmissions to intensive care unit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All cause mortality | participants will be followed for the duration of hospital stay, an expected average of 3 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Length of time in intensive care | participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Ventilation days | participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
| Use of vasopressors | participants will be followed for the duration of hospital stay, an expected average of 3 weeks |
| Thyroid hormones levels | participants will be followed for the duration of hospital stay, an expected average of 3 weeks |
Countries
Mexico
Outcome results
None listed