Central Serous Chorioretinopathy
Conditions
Keywords
Central serous chorioretinopathy, photodynamic therapy, safe and effective dose
Brief summary
To find the safe effective lowest light dose for photodynamic therapy (PDT). in the treatment of central serous chorioretinopathy.
Interventions
PROCEDUREPhotodynamic therapy
Photodynamic therapy is performed using verteporfin. Full dose of verteporfin is infused for 10 minutes, followed by laser delivery at 15 minutes from the start of infusion. Different light dose of PDT is applied to the patients at 50%, 40% and 30% of the full energy based on TAP study. The area of irradiation is set to the abnormal choroidal vascular hyperpermeability on ICGA corresponding to the leaking area on FA.
Sponsors
Yeungnam University College of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Idiopathic detachment of the neurosensory retina with a focal leak at the level of the RPE with FA 2. Presence of SRF and/or serous pigment epithelial detachment on optical coherence tomography (OCT) 3. Presence of abnormal dilated choroidal vasculature in ICGA 4. Patients with symptomatic CSC of at least 3 months duration
Exclusion criteria
1. Patients who received any previous treatment, including PDT or focal thermal laser photocoagulation for CSC, or who had evidence of CNV, PCV, or other maculopathy on clinical examination, FA, or ICGA 2. Patients receiving exogenous corticosteroid treatment 3. Patients with systemic diseases such as Cushing's disease or renal diseases 4. Pregnant patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of best corrected visual acuity | 6 month | Changes of best corrected visual acuity at baseline and 1, 3, 6 month after PDT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of central retinal thickness, success rate, recurrence rate, and complications | 6 months | Change of the central retinal thickness on optical coherence tomography (OCT)are compared at baseline at 1, 3, and 6 months after PDT. Additionally, success rate, recurrence rate, and complications between three groups are evaluated during 6 months. |
Countries
South Korea
Contacts
Primary ContactMin Sagong
Outcome results
None listed