Mechanical Ventilation Complication, Thoracic Surgery, Inflammation
Conditions
Brief summary
The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.
Interventions
PROCEDUREprotective ventilation
low tidal volume and PEEP
PROCEDURERecruitment maneuver combined with protective ventilation
Low tidal volume, PEEP and recruitment maneuver
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 20 Years and older * Patients undergoing thoracic surgery
Exclusion criteria
* Emergency surgery * Heart failure * Pulmonary hypertension * Forced vital capacity or forced expiratory volume in 1 sec \< 50% of the predicted values * Coagulation disorder * Pulmonary or extrapulmonary infections * History of treatment with steroid in 3 months before surgery * History of recurrent pneumothorax * History of lung resection surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of IL-8, TNFa in the bronchoalveolar lavage | up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Levels of IL-1, IL-6, IL-10 in the bronchoalveolar lavage | up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery | — |
| plasmatic concentration of inflammatory mediators IL-1, IL-6, IL-8, IL-10, TNFa | up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery | — |
| oxygenation | 1 hour after extubation | Changes in PaO2/FIO2 ratio |
| Chest-X ray | 7 days after surgery | — |
Countries
South Korea
Outcome results
None listed