Prospective Randomized Controlled Multicenter Trial of 4 Antiseptic Strategies for Prevention of Catheter Infection in Intensive Care Unit for Adults Patients

Conditions

Preventing Catheter Related Infection

Brief summary

Catheter related infection is the third cause of nosocomial infection in ICUs. Most of them are avoidable and can be prevent by improving aseptic practices during catheter insertion and maintenance. Indeed, the main route of catheter contamination for short-term catheters is the insertion site. Consequently, the quality of skin disinfection is the most effective preventive measure to reduce the incidence of these infections. This aim of the present study is to compare four strategies of skin disinfection to determine whether a 2% alcoholic solution of chlorhexidine acts better than 5% alcoholic povidone iodine in reducing catheter infection and to assess whether a detersion phase prior to disinfection reduces catheter colonization as compared with no detersion.

Jeanne Iachkine, Niccolò Buetti, Harm‐Jan de Grooth, Anaïs R. Briant, Olivier Mimoz et al. (13 authors)

Annals of Intensive Care2023-01-161 citations

10.1186/s13613-023-01099-9

Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials

Jeanne Iachkine, Niccolò Buetti, Harm‐Jan de Grooth, Anaïs R. Briant, Olivier Mimoz et al. (13 authors)

Critical Care2022-07-079 citations

10.1186/s13054-022-04078-x

Ultrasound guidance and risk for intravascular catheter-related infections among peripheral arterial catheters: a post-hoc analysis of two large randomized-controlled trials

Niccolò Buetti, Stéphane Ruckly, Jean‐Christophe Lucet, Lila Bouadma, Carole Schwebel et al. (7 authors)

Annals of Intensive Care2020-07-0814 citations

10.1186/s13613-020-00705-4

Cost-effectiveness analysis of chlorhexidine-alcohol versus povidone iodine-alcohol solution in the prevention of intravascular-catheter-related bloodstream infections in France

Franck Maunoury, Christian Farinetto, Stéphane Ruckly, Jérémy Guénézan, Jean‐Christophe Lucet et al. (10 authors)

PLoS ONE2018-05-2513 citations

10.1371/journal.pone.0197747

Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial.

Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF, CLEAN trial investigators.

2015-09-18195 citations

10.1016/s0140-6736(15)00244-5

Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial.

Goudet V, Timsit JF, Lucet JC, Lepape A, Balayn D, Seguin S, Mimoz O.

2013-04-278 citations

10.1186/1745-6215-14-114

Interventions

PROCEDUREskin disinfection prior catheter insertion

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* ≥ 18 year-old * Expected duration of ICU stay ≥ 48 hours * Patient requiring the insertion of at least one arterial catheter and/or central venous catheter and/or catheter for hemodialysis.

Exclusion criteria

* Patient with history of allergy to any of the antiseptic agent studied * Expected survival \< 48 hours * Catheter inserted outside the ICU or in emergency without respect of preventive measures. * Use of antimicrobial impregnated catheters or antiseptic impregnated dressings. * Pregnant woman or breast-feeding mother

Design outcomes

Primary

Measure	Time frame
Major catheter related infection	—

Secondary

Measure	Time frame
Catheter related bacteremia	—
Colonization insertion site	—
Prolongation hospitalization due to catheter infection	—
Catheter colonization	—
Skin allergy and anaphylactic shock	—
Costs	—
Mortality due to catheter infection	—

Countries

France

Outcome results

None listed