Essential Hypertension
Conditions
Keywords
men and women, in southwestern Han Chinese
Brief summary
The purpose of this study is to investigate the association between GRK4 polymorphisms and essential hypertension in southwestern Han Chinese and test whether these polymorphisms were associated with the changes in blood pressure in patients with essential hypertension treated with angiotensin II Type antagonist candesartan.
Detailed description
All antihypertensive agents were withdrawn before the start of a 4-6 week, single-blind, after which the patients received candesartan 10 mg or 20mg once daily as monotherapy in a single-blind fashion. The doses were doubled after 1 weeks if DBP was ≥ 90 mmHg.
Interventions
DRUGCandesartan
To investigate the response to candesartan among southwestern Han Chinese with essential hypertrension
Sponsors
Third Military Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* men and women with mild to moderate essential hypertension in southwestern Han Chinese
Exclusion criteria
* subjects unwilling to participate or subjects did not have all measurement required, * subjects who were on medications, which affect blood pressure or * whose DNA failed to amplify and 8 with errors in Mendelian segregation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The subjects with GRK4 varirants may exert different response during 4 weeks of treatment with candesartan in patients with essential hypertension | two years |
Countries
China
Contacts
Primary ContactYu changqing, Doctor
Outcome results
None listed