Coronary Artery Bypass Graft, Median Sternotomy
Conditions
Keywords
sternal wound infection, coronary artery bypass graft, risk factor
Brief summary
The investigators are trying to evaluate the performance of neutrophil and lymphocyte counts as a risk factor of deep sternal wound infection after coronary artery bypass graft surgery.
Detailed description
Deep sternal wound infection after coronary artery bypass graft is a very dangerous complication as it prolongs hospital stay, increase morbidity and mortality, and increase cost of care. As a risk factor of surgical site infection, risk index reported by NNIS (national nosocomial infection surveillance), Euroscore, or Society of thoracic surgeon risk score are currently used. However, as various performances are reported regarding these index or scoring systems, and many factors are needed for these index or scoring system, there is a need to develop a more simple risk factor with better performance. We focused on the differential blood cell count, as the neutrophil and lymphocyte count are related to the degree of surgical invasion, and inflammatory response. Previous studies reported that the neutrophilia or lymphopenia is related to postoperative infection. Therefore, we are trying to evaluate the performance of preoperative or postoperative the blood cell differential count as a risk factor for sternal wound infection after coronary artery bypass surgery.
Interventions
None listed
Sponsors
Samsung Medical Center
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Those underwent coronary artery bypass graft surgery with median sternotomy in Samsung Medical Center during the period of January 2008 and December 2011.
Exclusion criteria
* Those underwent coronary artery bypass graft surgery with mini-thoracotomy * Those with insufficient study data recognized by electronic medical record
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative surgical wound infection | within first week after the end of coronary artery bypass graft surgery | postoperative surgical wound infection within first week after the end of coronary artery bypass graft surgery, classified as a superfical or deep sternal wound infection |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| preoperative total leukocyte count | 1 day before surgery | preoperative total leukocyte count |
| preoperative neutrophil count | 1 day before surgery | preoperative neutrophil count |
| preoperative lymphocyte count | 1 day before surgery | preoperative lymphocyte count |
| postoperative total leukocyte count | 2 hour after the end of surgery | postoprative total leukocyte count |
| Preoperative STS | 1 day before surgery | Preoperative STS (Society of Thoracic Surgeons risk score) |
| postoperative lymphocyte count | 2 hour after the end of surgery | postoperative lymphocyte count |
| preoperative NNIS risk index | 1 day before surgery | preoperative NNIS risk index |
| preoperative EuroScore | 1 day before surgery | preoperative EuroScore |
| the incidence of surgical reopen with surgical wound infection | within 1 month after surgery | the incidence of surgical reopen with surgical wound infection |
| postoperative neutrophil count | 2 hour after the end of surgery | postoperative neutrophil count |
Countries
South Korea
Contacts
Primary ContactSangmin M. Lee, MD, PhD
Backup ContactWon Ho Kim, MD
Outcome results
None listed