Comparison of the Bilateral TAP Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study

Comparison of the Bilateral Transversus Abdominis Plane (TAP) Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01628952

Enrollment

Registered

2012-06-27

Start date

2012-10-04

Completion date

2013-03-27

Last updated

2026-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The Main of This Study is to Compare the Nerve Block of the Muscles of the Abdominal Wall Between the Bilateral TAP Block and Curare

Brief summary

This is a Biomedical Research, prospective, randomized, controlled single-blind mono centric, phase IV comparison trial of the bilateral TAP block versus curare in muscle relaxation of the abdominal wall during laparoscopic digestive surgery.

Interventions

DRUGTransversus Abdominis Plane

PIA coelioscopic

DRUGCurare

IAP coelioscopic

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients older than 18 years and under 75 years * Informed consent signed * ASA I, II and III * Patient affiliated to social security

Exclusion criteria

* ASA IV * BMI\> 35 kg / m * Personal or family history of malignant hyperthermia * History of allergy or hypersensitivity to intravenous anesthetics (remifentanil), local anesthetics or muscle relaxants * Contraindications to sevoflurane: a history of malignant hyperthermia, history of liver disease after sevoflurane anesthesia, halogenated agents or hypersensitivity to any of these components. * Contraindications to succinylcholine: hyperkalemia, plasma cholinesterase deficiency nickname, para or tetraplegia more than 24 hours, burns over 24 * Contraindications to cisatracurium: myasthenia * Neuromuscular diseases * Contraindications to local anesthetics: hypersensitivity to local anesthetics of the amide, intravenous regional anesthesia, porphyria, ventricular atrial conduction disturbances, epilepsy uncontrolled by treatment * Pregnancy and lactation * severe coagulation disorders * Inability to understand and give informed consent * Patient under guardianship, curatorship or protected * Indication of use of a hypnotic ketamine (BIS change)

Design outcomes

Primary

Measure	Time frame	Description
Muscle relaxation.	20 minutes after anesthesia induction	Muscle relaxation of the abdominal wall will be evaluated based on the amount of volume infused initially to create the pneumoperitoneum. This parameter is given by the unit of laparoscopy and allow us to calculate the abdominal compliance (C = ΔV / Ap).

Countries

France

Contacts

STUDY_DIRECTORHervé DUPONT, PU-PH

CHU Amiens France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 13, 2026