Brain Functional Connectivity Changes Following Cognitive Rehabilitation in Multiple Sclerosis: an fMRI Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01628276

Enrollment

Registered

2012-06-26

Start date

2012-07-31

Completion date

2013-10-31

Last updated

2014-09-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MS (Multiple Sclerosis)

Keywords

Multiple Sclerosis, MRI Scans

Brief summary

This trial seeks to investigate brain network changes following cognitive rehabilitation in MS patients. The investigators hypothesize that rehabilitation interventions improve connectivity in the brain.Novel Magnetic Resonance Imaging technique is performed to investigate changes in brain plasticity.

Interventions

BEHAVIORALCog Rehab

Cognitive rehab for MS patients

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 54 Years

Healthy volunteers

Yes

Inclusion criteria

* Definitive MS diagnosis * Right handedness * EDSS 0-4 * No relapse in past 6 weeks * Willing to consent and participate in the study

Exclusion criteria

* Pregnancy * Left handedness * Neurologic or psychiatric disorder other than MS

Design outcomes

Primary

Measure	Time frame	Description
functional connectivity	0, 2nd, 4th Month	Changes in correlation of brain activity in different regions of brain as assessed by Blood Oxygenation Level Dependent (BOLD) signal

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026