Traumatic Brain Injury
Conditions
Keywords
Traumatic Brain Injury, long-term outcome, Brain Reserves, Cognitive Reserves, Emotional Reserves, Patients 1 year or more after Moderate or Severe Traumatic Brain Injury
Brief summary
It is hypothesized that the long-term results of rehabilitation and subsequent aging after Brain Trauma depend on brain's premorbid anatomical (structural) and functional (cognitive, emotional) reserves. The purpose of this study are: 1. to determine whether such reserves exist. 2. to study their convergent and discriminant validity. 3. to study their characteristics.
Interventions
DEVICEBrain MRI
Brain MRI
DEVICEMRI
Physical examination Neuropsychological testing Questionnaires
Sponsors
Sheba Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Moderate-Severe Traumatic Brain Injury according to at least 1 the following: * Duration of loss of consciousness (LOC) - more then 1/2 hour * Glasgow Coma Scale (GCS) - less then 13 * Post Traumatic Amnesia (PTA) - more then 24 hours. * At least 1 year after the injury.
Exclusion criteria
* Mild Traumatic Brain Injury * the present state of Post Traumatic Amnesia * dementia * the age less than 18 years on the moment of injury * less than 1 year since the injury * incapacity of the patient to cooperate in the study (incapacity of any source including physical, mental, and language problems) * premorbid diagnosis of Mental Retardation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological battery | neuropsychological baterry for every participant will be performed during 3-4 meetings. An expected average for complete neuropsychological assessment is about 8 weeks |
Countries
Israel
Outcome results
None listed