Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

A Randomized Trial to Evaluate Effectiveness of Acetazolamide in COPD Patients Developing Metabolic Alkalosis During Invasive Mechanical Ventilation

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01627639

Acronym

DIABOLO

Enrollment

380

Registered

2012-06-26

Start date

2011-10-31

Completion date

2014-07-31

Last updated

2015-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decompensated Chronic Obstructive Pulmonary Disease

Brief summary

The purpose of this study is to determine whether acetazolamide are effective to reduce the length of mechanical ventilation in decompensated Chronic Obstructive Pulmonary Disease (COPD) patients developing pure or mixed metabolic alkalosis.

Detailed description

The purpose of this study is to determine whether acetazolamide is effective to reduce the length of mechanical ventilation in decompensated COPD patients developing pure or mixed metabolic alkalosis.

Interventions

DRUGAcetazolamide

Acetazolamide (1 g IV per day or 2 g IV per day if coprescription of loop diuretics) or Placebo (saline serum) when pure or mixed metabolic alkalosis being present until planned extubation

DRUGPlacebo

Placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Decompensated COPD on invasive mechanical ventilation Less than 24 hours

Design outcomes

Primary

Measure	Time frame
length of invasive mechanical ventilation	within the first 28 days after intubation

Secondary

Measure	Time frame	Description
length of ICU stay	once at the end of ICU stay or at Day 28	Data collected once at the end of ICU stay or at Day 28
ICU mortality	once at the end of ICU stay or at Day 28	Data collected once at the end of ICU stay or at Day 28
numbers of nosocomial infections	every day during 28 days	data retrieved every day, until extubation or at the end of invasive ventilation in the tracheotomy
Length of weaning from mechanical ventilation	once at the extubation or at day 28	data retrieved once, at the extubation or at the end of invasive ventilation in the tracheotomy
weaning success	once at the end of ICU stay or at Day 28	Data collected once at the end of ICU stay or at Day 28

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026