Acute Pancreatitis
Conditions
Keywords
severe acute pancreatitis;, continuous regional arterial infusion;, low molecular weight heparin
Brief summary
Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished). In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.
Interventions
PROCEDUREContinuous regional arterial infusion of low molecular weight heparin in celiac trunk
Put a catheter to the celiac trunk through interventional technique. The approach to celiac trunk was via a femoral artery approach.The tip of the arterial catheter (4F) was placed in celiac trunk which could perfuse the pancreas.After that, continuous infusion of low molecular weight heparin through the catheter will be applied during the first 5 days after placement.
OTHERGeneral treatment
Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc.
Sponsors
Nanjing University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Symptoms and signs of severe acute pancreatitis according to Atlanta criteria * Within 3 days from the onset of the disease * Available for interventional treatment(not sensible to radiocontrast agent)
Exclusion criteria
* Pregnant pancreatitis * Receiving surgery or aspiration before;need of early surgery * Patients with coagulation disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| coagulation related complications | 14 days after the placement of celiac trunk catheter | bleeding for the most coagulative parameters |
| Pancreatic infection | 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| pancreatic necrosis | 28 days |
| ICU duration | Participants will be followed until the date of discharge from the ICU,assessed up to 6 weeks. Patients who die during hospitalization are excluded from this measurement. |
| Hospital duration | Participants will be followed until the date of discharge from the hospital,assessed up to 3 months. Patients who die during hospitalization are excluded from this measurement. |
| Mortality | Participants will be followed until the date of discharge or the date of death from any cause, whichever came first, assessed up to 3 months |
Countries
China
Contacts
Primary ContactWeiqin Li, Dr
Backup ContactZhihui Tong, Dr
Outcome results
None listed