A Trial of an Oral Nutritional Supplement in Older Hospitalized Patients - NOURISH Study

Conditions

Hospitalized Elderly

Brief summary

Evaluate effects of an oral nutritional supplement on healthcare outcomes in older hospitalized adults. Also referred to as the NOURISH Study - Nutrition effect On Unplanned Readmissions and Survival in Hospitalized patients.

Geraldine Baggs, Carly Middleton, Jeffrey L. Nelson, Suzette L. Pereira, Refaat M. Hegazi et al. (10 authors)

Clinical Nutrition2023-09-0913 citations

10.1016/j.clnu.2023.09.004

Specialized oral nutritional supplement (ONS) improves handgrip strength in hospitalized, malnourished older patients with cardiovascular and pulmonary disease: A randomized clinical trial.

Matheson EM, Nelson JL, Baggs GE, Luo M, Deutz NE.

2020-09-0536 citations

10.1016/j.clnu.2020.08.035

Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial

Nicolaas E.P. Deutz, Eric M. Matheson, Laura E. Matarese, Menghua Luo, Geraldine Baggs et al. (9 authors)

Clinical Nutrition2016-01-18451 citations

10.1016/j.clnu.2015.12.010

Interventions

OTHERReady to Drink Flavored Beverage

2 servings a day

OTHERReady to drink flavored beverage w/ AN 777

2 servings a day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

No

Inclusion criteria

1. Male or female ≥ 65 years of age. 2. Admitted to hospital with diagnosis of heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease. 3. Subjective Global Assessment rating of B or C. 4. Length of hospital stay anticipated to be \> 3 days and \< 12 days 5. Able to consume foods and beverages orally. 6. Functionally ambulatory during the 30 days prior to admission.

Exclusion criteria

1. Uncontrolled hypertension 2. Diagnosis of diabetes 3. Current active cancer or recently treated cancer 4. Impaired renal function 5. Liver failure, acute Hepatitis, or hepatic encephalopathy 6. Active tuberculosis. 7. HIV 8. Disorder of gastrointestinal tract 9. Autoimmune disorder 10. Intubation, and/or tube or parenteral feeding. 11. Severe dementia or delirium, brain metastases, eating disorder, history of significant neurological or psychiatric disorder, alcoholism, substance abuse or other conditions that may interfere with study product consumption or compliance with study protocol procedures 12. Allergy or intolerance to any of the ingredients in the study products. 13. Body mass index of ≥ 40 kg/m2. 14. Resident in a nursing home or other residential facility. 15. Planned surgery during course of the study.

Design outcomes

Primary

Measure	Time frame
Return to hospital or death	90 days

Secondary

Measure	Time frame	Description
Return to hospital or death	30 and 60 days	—
Hospital Days	90 days	—
Activities of Daily Living	90 days	Katz Activities of Daily Living at entry and 90 days

Countries

Puerto Rico, United States

Outcome results

None listed