Effectiveness Registry to Study Therapies for Arthritis and Inflammatory Conditions: The Corrona CERTAIN Sub-study

Conditions

Rheumatoid Arthritis

Keywords

Rheumatoid Arthritis, Registry, RA, Biologic, Medications, Rheumatology

Brief summary

The CORRONA CERTAIN Sub-study of the Consortium of Rheumatology Researchers of North America, Inc. is a Sub-study of the CORRONA Data Collection Program. The CERTAIN Sub-study is designed to systematically collect and document use patterns, effectiveness, comparative effectiveness and safety of biologic agents used in the management of Rheumatoid Arthritis (RA).

Detailed description

Biologic therapies (including biologic medications like Enbrel, Humira, Remicade, Cimzia, Simponi, Actemra, Rituxan and Orencia) have changed the treatment of RA, but the differences in safety and/or effectiveness of each biologic therapy are not all known. We are doing this study in order to try to see if one or more of these treatments are better than the others. The use of databases like the CORRONA Organization database gives us information that helps us to understand why such drugs are used, reasons for starting or stopping drugs, for whom they are prescribed, and to monitor changes in patients' abilities to perform daily activities and gather information on family or social history.

Harrold LR, Bryson J, Lehman T, Zhuo J, Gao S, Han X, Schrader A, Rebello S, Pappas DA, Sommers T, Kremer JM.

2021-05-2811 citations

10.1007/s40744-021-00310-2

Comparative Effectiveness of Abatacept Versus Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis Who Are Anti-CCP Positive in the United States Corrona Registry.

Harrold LR, Litman HJ, Connolly SE, Alemao E, Kelly S, Rebello S, Hua W, Kremer JM.

2019-03-1316 citations

10.1007/s40744-019-0149-3

Dosing of Intravenous Tocilizumab in a Real-World Setting of Rheumatoid Arthritis: Analyses from the Corrona Registry

Dimitrios A. Pappas, Ani John, Jeffrey R. Curtis, George Reed, Chitra Karki et al. (9 authors)

Rheumatology and Therapy2016-02-088 citations

10.1007/s40744-016-0028-0

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* The CORRONA CERTAIN Sub-study is particularly focused on understanding the effectiveness and safety of biologic medications. Male and female patients, who 1. are at least 18 years of age; 2. have a documented diagnosis of RA by their treating rheumatologist; 3. have at least moderate disease activity; and 4. are initiating a biologic agent that has not be used for their treatment in the past are eligible to participate. Moderate disease activity is defined by a CDAI score greater than 10.

Exclusion criteria

Disease other than RA that do not meet the inclusion criteria

Countries

United States

Outcome results