Eosinophilic Esophagitis
Conditions
Brief summary
The purpose of the study is to investigate if serological parameters such as extracellular Serum-Tryptase (ST) and eosinophilic cationic protein (ECP) are useful for the diagnosis and surveillance of the eosinophilic esophagitis (EE).
Detailed description
The eosinophilic esophagitis (EE) is chronic inflammatory and immunological disease. The diagnosis of EE is based upon large numbers of eosinophils in the esophagus on histopathologic examination (\> 20 eosinophils per high powered field in at least one specimen) despite acid suppression with a Proton-Pump-Inhibitor (PPI) for at least two weeks. There are no diagnostic serological markers for EE so far, so that the purpose of the study is to investigate serological markers which are established in other allergic diseases.
Interventions
DRUGFluticasone
Guideline-based treatment with fluticasone 0,5 ml (1-0-1), step-up or step-down after 3 months based on the histopathological findings
Sponsors
Technical University of Munich
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* histopathological defined eosinophilic esophagitis * Age: 18-80
Exclusion criteria
* missing consent form * contraindications for performing esophagogastroscopy/taking biopsies of the esophagus
Countries
Germany
Contacts
Primary ContactMonther Bajbouj, MD
Backup ContactChristoph Schlag, MD
Outcome results
None listed