Acute Phase Reaction, Confusion, Delirium, Inflammation, Surgery
Conditions
Keywords
Laparoscopy, Surgery, Acute Phase Reaction, Aged, Aged 80 and over, Confusion, Inflammation, Delirium
Brief summary
A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.
Detailed description
Cognitive changes in the elderly are common after surgery. It is not known if minimally invasive or laparoscopic surgery can prevent these changes. A study will be conducted on patients scheduled to have abdominal surgery. The patients will have cognitive evaluations before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. The results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.
Interventions
None listed
Sponsors
New York State Department of Health
New York Hospital Queens
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients over age 65.0 years and in need of elective colon resection for adenocarcinoma
Exclusion criteria
* Inability to complete preoperative cognitive screening * Inability to complete study in English since CANTAB is timed and not validated with interpreters * Emergency surgery * Depression or psychiatric comorbidity * Pre-existing dementia * Previous cerebrovascular accident or stroke * Previous myocardial infarction * Cardiac ejection fraction below 55% * Propranolol, metoprolol or other betablocker use * Digoxin, procainamide, or amiodarone use * Calcium channel blocker use * History of vascular surgery or arterial vascular disease * History of alcohol dependence * Lovastatin or other HMG-CoA reductase inhibitor use * Ace inhibitor use * Neuroendocrine or catecholamine associated tumors * Hypertension * Diabetes * Benzodiazepine use * Dimenhydrinate or other medications to treat motion sickness * Metaclopramide use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Confusion | 6 Months | Confusion assessed by questionaires and cognitive testing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| degree of inflammation | 6 Months | 5 separate blood draws |
| presence of electrolyte imbalance | 6 months | 5 separate blood draws |
| pituitary-thyroid axis disruption | 6 months | 5 separate blood draws |
| liver function tests | 6 months | 5 separate blood draws |
| nutritional status | 6 months | 5 separate blood draws |
Countries
United States
Contacts
Primary ContactMitchell Chorost, MD
Backup ContactMitchell I Chorost, MD
Outcome results
None listed