Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01622751

Enrollment

Registered

2012-06-19

Start date

2007-01-31

Completion date

2007-06-30

Last updated

2012-06-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Prader-Willi Syndrome

Keywords

REM sleep, Adiponectin, Prader-Willi syndrome

Brief summary

Context: Adiponectin is an adipose tissue-derived hormone with an insulin sensitizing effect, and has been related to obstructive sleep apnea syndrome. In addition, children with Prader-Willi syndrome (PWS) suffer from excessive daytime sleepiness and the abnormality of rapid eye movement (REM) sleep. Objective: To determine if the sleep stages are related to the plasma levels of adiponectin, resistin, and RBP4 (retinol binding protein-4), and whether these relationships are influenced by age, obesity and insulin resistance.

Detailed description

This comparative study was carried out in 28 PWS children and 18 controls. The enrolled PWS children were volunteers out of a pool of approximately 100 PWS children followed at Samsung Medical Center \[median age 8.0 years, interquartile range (7.0-10.5 years), BMI: median 24.2 kg/m2 (23.0-27.5 kg/m2)\] and 18 obese healthy children \[median age 9.0 years interquartile range (7.0-11.0 years), BMI: median 24.2 kg/m2 interquartile range (23.1-27.6 kg/m2)\].

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 12 Years

Healthy volunteers

Yes

Inclusion criteria

* Prader Willi syndrome healthy children

Exclusion criteria

* history of seizure, * mental or brain illness, * adenoidectomy, * tonsillectomy, * craniofacial anomalies and any treatment at the time of the study.

Outcome results