FindTrial
Sign In

Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic Pain After Hysterectomy

Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic

Status
Withdrawn
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01622335
Enrollment
0
Registered
2012-06-19
Start date
2012-05-31
Completion date
2023-12-31
Last updated
2024-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Hysterectomy (& Wertheim), General Anesthesia, Nitrous Oxide

Brief summary

The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups.

Detailed description

The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.

Interventions

DRUGNitrous oxide

General anesthesia with Nitrous Oxide, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg.

OTHERGeneral anesthesia with oxygen

General anesthesia with(Air, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg.

Sponsors

The Cleveland Clinic
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* 18 to 65 years old at time of the first procedure * Female * American Society of Anesthesiologists physical status I or II * Hysterectomy undergoing the general anesthesia

Exclusion criteria

* Neuropathic disease * Chronic opioid users * Contraindication for Nitrous Oxide receive * Consent will not be obtained patient * Psychiatric disorders * Current or recent drug abuse (within past 6 months).

Design outcomes

Primary

MeasureTime frameDescription
Nitrous oxide and chronic pain30 days post operativeThe of the effect of 50% N20/50% O2 on post hysterectomy in prevention of chronic pain.
Nitrous oxide and opioid consumption4 hours post operativeThe effect of 50% N20/50% O2 on post hysterectomy in decrease of opioid consumption.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026