Nitrous Oxide On Acute Postoperative Pain and Opioid Consumption and Chronic Pain After Inguinal Hernia Repair Surgery

Effect Nitrous Oxide On Acute Postoperative Pain and Opioid Consumption and Chronic Pain After Inguinal Hernia Repair Surgery

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01622322

Enrollment

Registered

2012-06-19

Start date

2012-05-31

Completion date

2023-12-31

Last updated

2023-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inguinal Hernia Repair, Post Operative Pain

Brief summary

To compare postoperative pain, opioid consumption and chronic pain in patients undergoing to hernia repair surgery after receiving nitrous oxide or oxygen during the general anesthesia.

Detailed description

The study is prospective and double blind. In the clinic, patients undergoing inguinal hernia surgery that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups. In the first group of patients will receive Nitrous Oxide and In the second group of patients will receive oxygen during the general anesthesia.

Interventions

DRUGNitrous Oxide

Nitrous Oxide, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg.

OTHERoxygen

Subjects will receive General anesthesia: (Air, 70%, O2 30%) 1-5 L, Sevoflurane 1-2%, ETCO2: 32-35 mmHg.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* 18 to 65 years old at time of the first procedure * American Society of Anesthesiologists physical status I or II * Inguinal hernia repair surgery undergoing the general anesthesia

Exclusion criteria

* Neuropathic disease * Chronic opioid users * Contraindication for Nitrous Oxide receive * Consent will not be obtained patient * Psychiatric disorders * Current or recent drug abuse (within past 6 months).

Design outcomes

Primary

Measure	Time frame	Description
Nitrous oxide and chronic pain	30 days post operative	The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in prevention of chronic pain.
Nitrous oxide and opioid consumption	4 hours after surgery	The effect of 70% N20/30% O2 on post inguinal hernia repair procedure in decrease in opioid consumption.

Secondary

Measure	Time frame	Description
smoking and post operative pain	4 hours after surgery	The effect of active smoking to increase post operative acute pain.
smoking and chronic pain	30 days post operative	The effect of active smoking and chronic pain

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026