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Influence of Sodium Bicarbonate on Time-to-exhaustion at Critical Power in Endurance Athletes

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01621074
Enrollment
12
Registered
2012-06-15
Start date
2011-10-31
Completion date
2013-01-31
Last updated
2013-04-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Performance

Brief summary

During endurance exercise in the heavy and severe intensity domains, the rate at which metabolites that have been associated with the fatigue process (e.g. Pi, ADP, H, and extracellular K) accumulate increases. possibly leading to exercise cessation. Sodium bicarbonate, as a nutritional supplement, has gained attention over the past decades, because it might delay of offset fatigue. To date, there is a controversial discussion about which delivery mode (amount and frequency) might be best in optimizing endurance performance. Since the high ion load consequent to multiple ingestions might increase plasma volume, and consequently decrease bicarbonate concentrations, single acute ingestion could be more beneficial. However, in multi-day competitions or tournaments it might be necessary to use the supplement on a daily basis. Here, the investigators aim at investigating the effects of single dose or multiple dose (on five consecutive days) administration of bicarbonate vs. placebo increases endurance performance and acid-base homeostasis in trained male endurance athletes.

Interventions

DIETARY_SUPPLEMENTSodium bicarbonate

Ergogenic effect

DIETARY_SUPPLEMENTPlacebo

Placebo effect

Sponsors

Swiss Federal Institute of Technology
CollaboratorOTHER
University of Zurich
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

- male * no cold or temperature at beginning or during the study * between 18 and 45 years of age * active in endurance sports (3 to 5 times per week a moderate to hart training) * non-smoker * no known cardiovascular or orthopedic problems * no known limitations of kidney function * no bearer of a cardiac pacemaker * no medications with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant. * requirements of the health questionnaire fulfilled

Exclusion criteria

- female * male and age under 18 or over 45 years * cold or temperature at the beginning or during the study * untrained (less than 3 moderate trainings per week) * smoker * cardiovascular or orthopedic problems * limitations of the kidney function * bearer of a cardiac pacemaker * medication with direct influence on the measurements. The whole intake of medicaments has to be declared in the health questionnaire by the participant. * requirements of the health questionnaire not fulfilled

Design outcomes

Primary

MeasureTime frame
Time-to-exhaustion5 weeks

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 24, 2026