Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders

Sleep Apnea and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01621061

Enrollment

125

Registered

2012-06-15

Start date

2012-06-30

Completion date

2013-12-31

Last updated

2014-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Altitude Pulmonary Hypertension, Sleep Apnea

Keywords

high altitude illness, pulmonary hypertension, sleep apnea, hypoxia

Brief summary

High altitude pulmonary hypertension, a form of altitude illness that occurs in long-term residents at altitudes \>2500 m, is characterized by dyspnea, hypoxemia, impaired exercise performance and hypertension in the pulmonary circulation. Whether sleep related breathing disturbances, common causes of nocturnal hypoxemia in lowlanders, are also prevalent in highlanders and promote pulmonary hypertension in highlanders is unknown. Therefore, the current study will investigate whether highlanders with high altitude pulmonary hypertension have a greater prevalence of sleep apnea than healthy highlanders and lowlanders.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* high altitude pulmonary hypertension confirmed by clinical presentation and systolic pulmonary artery pressure \>50 mmHg measured by echocardiography at altitude of residence. * healthy subjects (high altitude controls) * Both genders * Age \>16 y * Kyrgyz ethnicity * born, raised and currently living at \>2500 m * healthy subjects currently living at \<1000 m (low altitude controls)

Exclusion criteria

* Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography * excessive erythrocytosis * other coexistent disorders that may interfere with the cardio-respiratory system and sleep * regular use of medication that affects control of breathing * heavy smoking

Design outcomes

Primary

Measure	Time frame	Description
Sleep related breathing disturbances	4 months	Nocturnal oxygen saturation and apnea/hypopnea index

Secondary

Measure	Time frame	Description
Dyspnea	4 months	NYHA functional class
Vigilance	4 months	Psychomotor vigilance
Exercise performance	4 months	6 min walk test
Pulmonary function	4 months	Spirometry
Pulmonary artery pressure	4 months	Echocardiography
Mountain sickness	4 months	Quinghai chronic mountain sickness score
Generic quality of life	4 months	SF-36 quality of life questionnaire
Disease specific quality of life	4 months	Kansas City Cardiomyopathy questionnaire
Subjective sleepiness	4 months	Epworth sleepiness scale
Cerebral oxygen saturation	4 months	Near-infrared spectroscopy

Countries

Kyrgyzstan

Outcome results