Tobacco Dependence
Conditions
Keywords
smoking cessation, tobacco dependence
Brief summary
Focus of this study was to determine if bupropion was more effective for smoking cessation when used alone or combined with nicotine gum.
Interventions
DRUGPlacebo bupropion-Placebo gum
Placebo bupropion twice daily + placebo nicotine gum as needed (up to 12 pcs/day)
DRUGbupropion + nicotine gum
150 mg bupropion twice daily plus 4 mg nicotine gum as needed (up to 12 pcs/day)
DRUGActive bupropion-Placebo gum
150mg bupropion twice daily plus placebo nicotine gum as needed (up to 12 pcs/day)
Sponsors
National Institutes of Health (NIH)
University of Wisconsin, Madison
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Smoke 10 or more cigarettes per day * Motivated to quit * No physical or mental health issues that would prevent participation * Not pregnant or willing to prevent pregnancy during treatment
Exclusion criteria
* Carbon monoxide (CO) breath test score below 10 parts per million (ppm) * Center for Epidemiologic Studies Depression Scale (CES-D) score greater than 16 * Heavy alcohol use * History of eating disorder * Suicidality
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 7-day point prevalence abstinence measured at 6 months | 6 months | No smoking, not evan a puff, during the 7 days prior to the 6 month follow-up |
Countries
United States
Outcome results
None listed