Fascicular Block, Latency Period, Motor Activity, Pain, Postoperative
Conditions
Keywords
brachial plexus, lidocaine, alfa 2 adrenergic receptor clonidine, orthopedic procedure
Brief summary
The purpose of this study is to determine whether different clonidine concentration on axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the sensory and motor block onset time and duration, postoperative analgesia duration, postoperative pain intensity
Detailed description
Brachial plexus blocks are frequently used in surgical procedures involving the upper limb because they facilitate surgical anaesthesia, muscle relaxation and post-operative analgesics. Various drugs are used to supplement local anaesthetics during brachial plexus block. Many studies in the literature show that clonidine, which is an alpha-2 agonist, prolongs the length of anesthesia and post-operative analgesia.4,5 However, clonidine's side effects-such as hypotension, bradycardia and sedation can limit its use. There are no studies comparing different clonidine concentrations on the axillary brachial block, so the hypothesis of the present study was that different clonidine concentrations and LA volumes may influence the anaesthesia and analgesia quality on this type of regional block.
Interventions
DRUGhigh Clonidine concentration
Clonidine 1 ml - 150 mcg on 20 ml de lidocaine 1,5% on axillary brachial plexus block for upper limb surgery
DRUGlow clonidine concentration
Clonidine 1 ml - 150 mcg on 40 ml of lidocaine 1,5% - single injection on axillary brachial plexus block for upper limb
DRUGLidocaine
Lidocaine 1,5% 20 ml 300 mg for single injection on axillary brachial plexus block for upper lim surgery
DRUGLidocaine 40 ml
Lidocaine 40 ml 1,5% 600 mg single injection for axillary brachial plexus block for upper limb surgery
Sponsors
Universidade Federal do Rio de Janeiro
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* both genders, * over 18 years old, * American Society of Anesthesiologists (ASA) 1 to 3
Exclusion criteria
* patients with chronic use of analgesics and non-steroidal anti-inflammatories drugs, * pregnant, * with infection at the puncture site, * coagulopathies or intolerance to drugs used in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sensorial and motor block duration | 24 hours after surgery | to compare two concentrations of clonidine on different volumes of lidocaine, in terms of sensorial and motor block duration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adverse effects of additive clonidine on axillary brachial plexus block in upper limb surgery | 24 hours after surgery | analyse the adverse effects of additive clonidine on axillary brachial plexus block in upper limb surgery |
| postoperative analgesia duration | 24 hours | to compare two concentrations of clonidine on different volumes of lidocaine, in terms of postoperative analgesia duration |
| sensorial and motor block onset time | 24 hours | to compare two concentrations of clonidine on different volumes of lidocaine, in terms of sensorial and motor block onset time |
| postoperative pain intensity | 24 hours | to compare two concentrations of clonidine on different volumes of lidocaine, in terms postoperative pain intensity |
Outcome results
None listed