Food (Shrimp) Allergy
Conditions
Keywords
tryptases, anaphylaxis, shrimp allergy
Brief summary
The purpose of this study was to investigate the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.
Detailed description
The diagnosis of anaphylaxis is based primarily on the clinical history. In some circumstances, inability to confirm the clinical diagnosis such as present with unusual manifestation, or when skin signs are absent likely contributes to underrecognition and undertreatment of the disease. Currently, products of mast cell activation (histamine and total tryptase) can be measure in clinical laboratories as markers of acute anaphylaxis events, however these tests have clinically relevant limitations. Therefore, development of laboratory tests with improved sensitivity and specificity that will support the clinical diagnosis of anaphylaxis are needed. In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.
Interventions
PROCEDUREshrimp challenge
Patients with history of shrimp allergy and positive skin tests to shrimp were recruited for shrimp challenges After shrimp challenges, patients with anaphylaxis defined as anaphylaxis group, patients with mild reactions defined as mild reaction group, and patients without symptom defined as control group
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* a history of shrimp allergy
Exclusion criteria
* severe anaphylactic reaction from seafood * pregnancy * underlying diseases such as cardiovascular, hepatobiliary, and renal diseases * on systemic corticosteroid or β-blocking agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of Serum tryptases | baseline and 60 minutes after the onset of symptoms |
Countries
Thailand
Outcome results
None listed