Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant

Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant: A Randomized Trial

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01619449

Enrollment

Registered

2012-06-14

Start date

2012-04-30

Completion date

2014-12-31

Last updated

2015-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Chronic Kidney Disease, End Stage Kidney Disease, Liver Disease

Keywords

Acute Kidney Injury, Continuous Renal Replacement Therapy, Liver Transplant

Brief summary

To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT

Detailed description

as above

Interventions

PROCEDURERenal replacement therapy

Liver transplant recipients receiving continuous renal replacement therapy for duration of liver transplant surgery.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age 18 or older and able to sign consent (or surrogate) * Receiving liver or combined liver-kidney transplant * eGFR \< or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease * Pre-operative potassium of \< or equal to 5.5 mEq/L

Exclusion criteria

* Pre-operative hemoglobin \< or equal to 7 g/dL * Pre-operative weight \> or equal to 125 kig

Design outcomes

Primary

Measure	Time frame	Description
Solute Clearance	Intra-operative time	To compare the clearance of solutes (ie. potassium, lactate, creatinine and blood urea nitrogen) by CRRT in renally impaired OLT recipients to OLT recipients who do not receive CRRT

Secondary

Measure	Time frame	Description
Renal function and patient outcomes	1 year post-operatively	To compare long-term maintenance of renal function (12 months) and other health outcomes in OLT recipients who received CRRT versus OLT recipients who did not receive OLT

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026