Atrial Dyssynchrony Syndrome, Heart Failure With Preserved Ejection Fraction, Left Atrio-ventricular Asynchrony
Conditions
Keywords
Heart failure with preserved ejection fraction, atrial dyssynchrony syndrome, left atrio-ventricular asynchrony, pacemaker, left atrial pacing therapy
Brief summary
The purpose of this study is to assess left atrial pacing therapy in patients with atrial dyssynchrony syndrome and heart failure with preserved ejection fraction.
Interventions
PROCEDUREpace make active/inactive cross over
Sponsors
Centre Hospitalier Universitaire Dijon
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 65 * Sinus rhythm, PR \< 220ms, QRS \< 110ms * Heart failure (NYHA class III-IV or II with hospitalization for heart failure) * Ejection Fraction \> 50%, restrictive mitral inflow, Lateral E/e' \> 12 or septal E/e' \> 15, Left atrial index volume \> 34 ml/m² * Atrial dyssynchrony syndrome: (TTE) inter-atrial time delay ≥ 70ms (difference between tricuspid and mitral P-A intervals or between mitral and tricupsid P-A' intervals with DTI) * Left atrio-ventricular asynchrony: Time Difference between tricupsid and mitral A wave duration ≥ 35ms.
Countries
France
Outcome results
None listed