CRPS, Unilateral Limb Pain of Origin Other Than CRPS
Conditions
Keywords
rubber hand illusion, CRPS, body image, body ownership
Brief summary
The present study investigates by means of the rubber hand illusion body image stability and sense of body ownership in patients with CRPS of the upper limb compared to patients with unilateral pain of origin other than CRPS and age and sex-matched healthy subjects.
Detailed description
In patients with CRPS of the upper limb distortions of body representation and impairments of sense of body ownership are well-known. To investigate the body schema and body image stability of these patients in comparison to patients with upper limb pain of origin other than CRPS and healthy subjects, we conducted a series of rubber hand illusions. This well - established paradigm is elicited by visuo-tactile stimulation of one´s own real hand and a visible hand and forearm prosthesis. The present study investigates 1) if and how far patients with CRPS are susceptible to experience the illusion 2) how far the illusion strength differs between CRPS and patients with unilateral pain of the upper limb of other origin and healthy subjects 3) how far parameters, e.g. neglect-like severity symptoms, body plasticity, empathy, duration of disease and pain intensity influence the illusion strength.
Interventions
PROCEDURErubber hand illusion
There were three consecutive trials of the RHI: 1. one control trial: asynchronous condition (3 Min.) 2. two experimental trials (conducted on both hands):synchronous condition (3 Min.),additionally watching the prosthesis being threatened (20 sec.)
Sponsors
Ruhr University of Bochum
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
every participant: * aged \> 18 years * written informed consent * free to withdraw participation at any time * adequate understanding of the german language Patients with CRPS: * patients with CRPS type 1 of the upper limb * clinical symptoms were diagnosed on the basis of the recently modified diagnostic research criteria (Harden, Bruehl et al., 2007) * proved by typical enhancement in the late phase of the 99m-technetium-triple-phase bone skeleton scintigraphy (Wüppenhorst, Maier et al., 2010) Patients with unilateral pain of the upper limb: * unilateral pain * pain of origin other than CRPS Healthy subjects: * age and sex matched to patients with CRPS * checked by the DFNS IMI questionnaire
Exclusion criteria
every participant: * inadequate understanding of the german language * missing informed consent * diabetes mellitus Patients with CRPS: -CRPS Type 2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| subjective illusion strength by a validated questionnaire | 1 hour | The illusion strength was measured subjectively by a validated questionnaire on a 7- point Likert scale,ranging from 0 (= disagree strongly) to 7 (= agree strongly). The questionnaire encompassed five slightly modified items of the German-translated questionnaire by Ocklenburg et al.(2011), following Botvinick & Cohen (1998).In the experimental conditions the questionnaire was additionally augmented by three further statements regarding the perception of the needle threat. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| objectified illusion strength by measure of skin conductance response (SCR) | 1 hour | The SCR represents an objective measure of participant´s identification with the artificial limb, indicating the autonomic nervous system arousal in anticipation of pain, while watching the prosthesis being harmed (Armel & Ramachandran, 2003; Ehrsson, Wiech, Weiskopf, Dolan & Passingham, 2007). In every trial, the SCR was recorded with Ag-AgCl electrodes from the thenar and hypothenar eminence of the non-tested hand. Conductivity was measured in micro-Siemens (1/Ohm). |
| Measurement of influences of the illusion strength | half an hour | Several questionnaires were used to assess current and average pain intensity (NRS 0-10), neglect-like severity symptoms (Frettloeh et al. 2006), Handedness (Oldfield,1971), body plasticity (TABP) (Desmond, Horgan et al., 2001), empathy (IRI) ( Davis, 1980) and DASH-score (German, Wind et al. 1999). |
Countries
Germany
Outcome results
None listed