Normal Pressure Hydrocephalus
Conditions
Keywords
Normal Pressure Hydrocephalus, Neuropsychological Test, Assessment of cognitive disorders/dementia, Neuropsychological assessment
Brief summary
A novel computerised neuropsychological test battery for normal pressure hydrocephalus (NPH) has been developed. The aim is to provide the clinician with a free of charge, standardized tool, assessing the cognitive decline or improvements in the cognitive domains specific for NPH. Results from the battery indicate good reliability and validity for the computerized tests Results from the computerised battery seems promising. However, ability for the battery to detect cognitive improvements after a shunt operation remains to be tested. Study objectives 1. Improvement after shunt. The aim of this study is to evaluate the effects of shunting on neuropsychological performance in NPH patients, using a computerized battery. 2. Feasibility. The ability to complete the test battery by the intended patient group will be tested. 3. Baseline profile. Baseline scores for NPH-patients will be compared to scores of healthy individuals (from previous study).
Interventions
None listed
Sponsors
Umeå University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Older than 60 years of age Probable INPH according to the NIH guidelines Planned shunt surgery based on a diagnosis of INPH.
Exclusion criteria
* Known cause for hydrocephalus (i.e., secondary NPH). Medical condition preventing cognitive testing (e.g. deafness, blindness). Patients not considered for shunt operation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychological outcome | 4.5 ± 1.5 months | INPH patients, who are shunt candidates, will complete a computerized battery at two occasions: (1) hospital admission (Baseline) at most 1 month prior to surgery, and (2) 4.5 ± 1.5 months after shunt operation (Post-Shunt). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mini mental state Examination | 4.5 ± 1.5 months | INPH patients, who are shunt candidates, at each center will complete the Mini Mental State Examination at: (1) hospital admission (Baseline) at most 1 month prior to surgery, and (2) 4.5 ± 1.5 months after shunt operation (Post-Shunt). |
| Feasibility | 4.5 ± 1.5 months | The number of patients who are able to complete individual subtests and the entire battery, will be monitored. |
| Baseline cognitive profile compared to healthy | — | The baseline cognitive profile of INPH-patients will be compared to healthy individuals (from previous study). |
Countries
Denmark, Sweden
Outcome results
None listed