Parkinson's Disease
Conditions
Keywords
Parkinson's disease, gut, colon, biopsies, LRRK2
Brief summary
The clinical and pathological similarities between LRRK2 related parkinsonism and idiopathic Parkinson's disease (PD) indicate that monogenetic LRRK2 parkinsonism may be a paradigm for the development of Lewy bodies disease, and a careful look at discrepancies between these two conditions may provide insight into the pathogenesis of PD. The early involvement of the enteric nervous system (ENS) during PD led to theories that an as yet unidentified external agent entering the ENS causes PD . If lesions of the ENS are found in patients who present with a genetic form of parkinsonism would go against this notion, and thus provide insight to the pathophysiology of the disease.
Interventions
Usual procedure
Sponsors
Nantes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 30-80, both genders * Parkinson's disease patients * Parkinson's disease patients with G2019S mutations * Controls: patient at risk of colic cancer for whom a coloscopy is required
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presence of alpha-synuclein aggregates in colonic biopsies using immunohistochemistry | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of intestinal permeability in biopsies using Ussing's chambers | 3 months |
Countries
France
Outcome results
None listed