Periprosthetic Bone Loss in Total Knee Replacement
Conditions
Keywords
osteoarthritis, periprosthetic bone loss, dual energy x-ray absorptiometry
Brief summary
The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.
Interventions
RADIATIONdual energy x-ray absorptiometry
before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* severe knee osteoarthritis * post menopausal women
Exclusion criteria
* immune disease * end stage of renal disease who receive dialysis * history of fracture at ipsilateral distal femur
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in bone mineral density | before the surgery and after the sugery (6month ,12month) | Use dual energy x-ray absorptiometry to detect to BMD at the distal femur |
Countries
Taiwan
Contacts
Primary ContactChing Chuan Jiang, professor
Backup ContactWei cheng Huang, resident
Outcome results
None listed