Thyroid Neoplasm
Conditions
Keywords
dexmedetomidine, remifentanil, target-controlled infusion
Brief summary
Remifentanil target-controlled infusion and dexmedetomidine single-dose administration are known to reduce airway response and haemodynamic stimulation during anaesthetic recovery. The investigators will compare the effects of two drugs on prevention of cough during emergence from general sevoflurane anaesthesia.
Interventions
DRUGdexmedetomidine
Fifteen minutes before the end of surgery, the first practitioner replace the syringe of remifentanil as new one; new syringe contains remifentanil in remifentanil group (Group R), and normal saline in dexmedetomidine group (Group D), respectively. There are no drug labeling in the new syringe, so the second practitioner can't know which drug was contained in the new syringe. Simultaneously, the second practitioner remifentanil concentration on monitor of TCI pump will be adjusted to 2.0 ng•ml-1. Ten minutes before the end of surgery, 10 ml of dexmedetomidine 0.5 mcg•kg-1 mixed with normal saline will be given for 5 min in Group D; in Group R, 10 ml of normal saline will be given by the first practitioner.
DRUGNormal Saline
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* female patient, * aged 20-60 yr, * ASA physical status 1-2, * patients undergoing elective thyroidectomy under general anesthesia
Exclusion criteria
* sighs of difficult airway, * history of respiratory disease or chronic cough, * cardiovascular disease, * pregnant or breast-feeding woman.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| coughing response | from discontinuation of anesthetic agent (sevoflurane) to 5 min after extubation. | Emergence cough was defined as the cough occurrence during peri-extubation period, from sevoflurane discontinuation to 5 min after extubation. The severity of cough was assessed and recorded by the following cough grading system: Grade 0, no cough; Grade 1, single cough with mild severity; Grade 2, cough persistence less than 5 s with moderate severity; Grade 3, severe, persistent cough for more than 5 s (bucking). |
Countries
South Korea
Outcome results
None listed