Leukemia
Conditions
Brief summary
The use of peripheral blood stem cells(PBSCs) is rapidly growing in the allogeneic transplantation setting as an alternative to bone marrow (BM).It was found that the use of PBSCs is associated with faster hematologic recovery but have yielded differing results regarding the incidence of graft-versus-host-disease (GVHD) and relapse. The study hypothesis: transplantation of mobilized PBSC to haploidentical donor with standard-risk leukemia had comparable engraftment and non-relapse mortality to mobilized BM combined with PBSCs
Detailed description
The donors were primed with granulocyte-colony stimulating factor (G-CSF) injected subcutaneously for five consecutive days. In the trial group, the PBSCs were harvested on the fourth and fifth day;in the control group, the bone marrow cells were harvested on the fourth day and the PBSCs were harvested on the fifth day.
Interventions
PROCEDUREtransplant with PBSCs
mobilized PBSCs for 2 consecutive days
Sponsors
Peking University People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Standard risk of Recipients of haploidentical stem cell transplantation with myeloablative conditioning regimens
Exclusion criteria
* Active, uncontrolled infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of engraftment | paticipants will be followed for the duration of hospital stay,an expected average of 30 days | number of participants with engraftment at 30d |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of non-relapse mortality | 1 year | number of participants with non-relapse mortality at 1 year |
Countries
China
Outcome results
None listed