Hypoxemic Acute Respiratory Failure
Conditions
Keywords
Cardiac surgery, Acute respiratory failure, High flow oxygen therapy
Brief summary
The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery.
Interventions
DEVICEOptiflow / Facial mask
J0: randomization (Optiflow® or facial mask), lung X-ray, kinesiotherapy H0 : clinical examination, blood gas, respiratory frequency H1 : clinical examination, blood gas, respiratory frequency H6 : clinical examination, blood gas J1: clinical examination, blood gas, respiratory frequency, lung X-ray, diaphragmatic echography, kinesiotherapy J2: clinical examination, blood gas, lung X-ray, kinesiotherapy Follow-up (until withdrawal of Optiflow or facial mask): clinical examination, blood gas, lung X-ray, kinesiotherapy
Sponsors
Nantes University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with indication of coronary artery bypass * Absence of preoperative respiratory failure * Hypoxia after extubation defined as SpO2 \< 96% with Venturi mask 50% 8L/min * Age \> 18 years * Signed informed consent
Exclusion criteria
* Patients requiring an imminent intubation, in coma or respiratory exhaustion, in a state of shock or severe rhythm disorders * Hemodynamic instability, low flow rate * Pneumothorax or hemothorax * Bleeding major, ischemic signs * Ventricular arrhythmia * Respiratory failure * Non controlled hyperalgia * Alteration of mental status * Cardiac surgery patients in post-operative valve surgery associated with coronary artery bypass surgery or isolated valve surgery * Pregnancy * Major under guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of PaO2/FiO2 ratio | One hour and 24 hours | The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Scale of satisfaction completed by the patient | at withdrawal of oxygen system | To evaluate the tolerance of high flow oxygen therapy: satisfaction scale |
| Measure of pH, SatO2, PaO2, FiO2 | 2 days | To evaluate hypoxia duration |
| Number of days of hospitalization | at day 28 | To evaluate the duration of hospitalization with the medical device |
| Measure of PCO2 and respiratory frequency | One day | To evaluate PCO2 and respiratory frequency at H+1 and J1 |
| Possibility of patient transfer in conventional service | at day 5 | To evaluate the reception in post reanimation if transfer under oxygen therapy |
Countries
France
Outcome results
None listed