Vocal Cord; Injury, Superficial
Conditions
Keywords
hoarseness, sore throat, vocal cord injuries
Brief summary
Vocal cord injuries occur not only during tracheal intubation, but also during surgery and during removal of tracheal tube. Volatile anesthetics increase neuromuscular block of muscle relaxants. Thus, the investigators tested the hypothesis, that sevoflurane would cause less vocal cord injuries than a total intravenous anesthesia with propofol.
Detailed description
Volatile anaesthetics increase neuromuscular block of neuromuscular blocking drugs. We tested the hypothesis, that sevoflurane would cause less vocal cord injuries than an intravenous anaesthesia with propofol. Sixty five patients were randomly assigned to the SEVO group (anaesthesia with sevoflurane) or TIVA group (anaesthesia with propofol). Vocal cord injuries were examined by stroboscopy before and 24 and 72 h after surgery; hoarseness was assessed up to 72 h.
Interventions
DRUGSevoflurane
Maintenance of anesthesia with sevoflurane 1.0 Vol%
DRUGpropofol
Maintenance of anesthesia with propofol
Sponsors
University of Rostock
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* orotracheal intubation * surgery of the ear * written consent * ASA I-III
Exclusion criteria
* preexisting pathologies of the vocal cords * obesity * difficult airway
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of vocal cord injuries | 24h after surgery | assessed by stroboscopy |
Secondary
| Measure | Time frame |
|---|---|
| incidence of hoarseness | 24h after surgery |
Countries
Germany
Outcome results
None listed